Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course

Muri, Jonathan; Cecchinato, Valentina; Cavalli, Andrea; Shanbhag, Akanksha A.; Matkovic, Milos; Biggiogero, Maira; Maida, Pier Andrea; Moritz, Jacques; Toscano, Chiara; Ghovehoud, Elaheh; Furlan, Raffaello; Barbic, Franca; Voza, Antonio; De Nadai, Guendalina; Cervia, Carlo; Zurbuchen, Yves; Taeschler, Patrick; Murray, Lilly A.; Danelon-Sargenti, Gabriela; Moro, Simone; Gong, Tao; Piffaretti, Pietro; Bianchini, Filippo; Crivelli, Virginia; Podešvová, Lucie; Pedotti, Mattia; Jarrossay, David; Sgrignani, Jacopo; Thelen, Sylvia; Uhr, Mario; Bernasconi, Enos; Rauch, Andri; Manzo, Antonio; Ciurea, Adrian; Rocchi, Marco B. L.; Varani, Luca; Moser, Bernhard; Bottazzi, Barbara; Thelen, Marcus; Fallon, Brian A.; Boyman, Onur; Mantovani, Alberto; Garzoni, Christian; Franzetti-Pellanda, Alessandra; Uguccioni, Mariagrazia; Robbiani, Davide F

doi:10.1038/s41590-023-01445-w

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Journal article

Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course

Muri, Jonathan ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Cecchinato, Valentina ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Cavalli, Andrea ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Shanbhag, Akanksha A. Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Matkovic, Milos Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Biggiogero, Maira Clinical Research Unit, Clinica Luganese Moncucco, Lugano, Switzerland
Maida, Pier Andrea Clinical Research Unit, Clinica Luganese Moncucco, Lugano, Switzerland
Moritz, Jacques ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Toscano, Chiara ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Ghovehoud, Elaheh ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Furlan, Raffaello Department of Biomedical Sciences, Humanitas University, Milan, Italy - Department of Internal Medicine, IRCCS Humanitas Research Hospital, Milan, Italy
Barbic, Franca ORCID Department of Biomedical Sciences, Humanitas University, Milan, Italy - Department of Internal Medicine, IRCCS Humanitas Research Hospital, Milan, Italy
Voza, Antonio Department of Biomedical Sciences, Humanitas University, Milan, Italy - Department of Emergency, IRCCS Humanitas Research Hospital, Milan, Italy
De Nadai, Guendalina Emergency Medicine Residency School, Department of Biomedical Sciences, Humanitas University, Milan, Italy
Cervia, Carlo ORCID Department of Immunology, University Hospital Zurich, University of Zurich, Switzerland
Zurbuchen, Yves ORCID Department of Immunology, University Hospital Zurich, University of Zurich, Switzerland
Taeschler, Patrick ORCID Department of Immunology, University Hospital Zurich, University of Zurich, Switzerland
Murray, Lilly A. ORCID Lyme and Tick-Borne Diseases Research Center at Columbia University Irving Medical Center, New York, USA
Danelon-Sargenti, Gabriela Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Moro, Simone Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Gong, Tao Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Piffaretti, Pietro Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Bianchini, Filippo Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Crivelli, Virginia ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Podešvová, Lucie ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Pedotti, Mattia ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Jarrossay, David ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Sgrignani, Jacopo ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Thelen, Sylvia Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Uhr, Mario Synlab Suisse, Bioggio, Switzerland
Bernasconi, Enos ORCID Regional Hospital Lugano, Ente Ospedaliero Cantonale, Lugano, Switzerland - Università della Svizzera italiana, Lugano, Switzerland
Rauch, Andri ORCID Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Switzerland
Manzo, Antonio ORCID Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation, University of Pavia, Italy
Ciurea, Adrian ORCID Department of Rheumatology, University Hospital Zurich, University of Zurich, Switzerland
Rocchi, Marco B. L. Department of Biomolecular Sciences, Biostatistics Unit, University of Urbino, Italy
Varani, Luca ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Moser, Bernhard Division of Infection & Immunity, Cardiff University School of Medicine, Cardiff, UK
Bottazzi, Barbara ORCID IRCCS Humanitas Research Hospital, Milan, Italy
Thelen, Marcus ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Fallon, Brian A. Lyme and Tick-Borne Diseases Research Center at Columbia University Irving Medical Center, New York, USA - Lyme Research Program at the New York State Psychiatric Institute, New York, USA
Boyman, Onur ORCID Department of Immunology, University Hospital Zurich, University of Zurich, Switzerland - Faculty of Medicine and Faculty of Science, University of Zurich, Switzerland
Mantovani, Alberto ORCID Department of Biomedical Sciences, Humanitas University, Milan, Italy - IRCCS Humanitas Research Hospital, Milan, Italy - The William Harvey Research Institute, Queen Mary University of London, UK
Garzoni, Christian Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, Lugano, Switzerland
Franzetti-Pellanda, Alessandra Clinical Research Unit, Clinica Luganese Moncucco, Lugano, Switzerland
Uguccioni, Mariagrazia ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Department of Biomedical Sciences, Humanitas University, Milan, Italy
Robbiani, Davide F ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland

2023

Published in:

Nature immunology. - 2023, vol. 24, p. 604-611

English Infection with severe acute respiratory syndrome coronavirus 2 associates with diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse coronavirus disease 2019 (COVID-19) outcomes. Here we discovered that antibodies against specific chemokines were omnipresent post-COVID-19, were associated with favorable disease outcome and negatively correlated with the development of long COVID at 1 yr post-infection. Chemokine antibodies were also present in HIV-1 infection and autoimmune disorders, but they targeted different chemokines compared with COVID-19. Monoclonal antibodies derived from COVID-19 convalescents that bound to the chemokine N-loop impaired cell migration. Given the role of chemokines in orchestrating immune cell trafficking, naturally arising chemokine antibodies may modulate the inflammatory response and thus bear therapeutic potential.

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