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Robbiani_2023_Nature_Nat Immunology
Journal article

Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course

  • Muri, Jonathan ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Cecchinato, Valentina ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Cavalli, Andrea ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Shanbhag, Akanksha A. Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Matkovic, Milos Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Biggiogero, Maira Clinical Research Unit, Clinica Luganese Moncucco, Lugano, Switzerland
  • Maida, Pier Andrea Clinical Research Unit, Clinica Luganese Moncucco, Lugano, Switzerland
  • Moritz, Jacques ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Toscano, Chiara ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Ghovehoud, Elaheh ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Furlan, Raffaello Department of Biomedical Sciences, Humanitas University, Milan, Italy - Department of Internal Medicine, IRCCS Humanitas Research Hospital, Milan, Italy
  • Barbic, Franca ORCID Department of Biomedical Sciences, Humanitas University, Milan, Italy - Department of Internal Medicine, IRCCS Humanitas Research Hospital, Milan, Italy
  • Voza, Antonio Department of Biomedical Sciences, Humanitas University, Milan, Italy - Department of Emergency, IRCCS Humanitas Research Hospital, Milan, Italy
  • De Nadai, Guendalina Emergency Medicine Residency School, Department of Biomedical Sciences, Humanitas University, Milan, Italy
  • Cervia, Carlo ORCID Department of Immunology, University Hospital Zurich, University of Zurich, Switzerland
  • Zurbuchen, Yves ORCID Department of Immunology, University Hospital Zurich, University of Zurich, Switzerland
  • Taeschler, Patrick ORCID Department of Immunology, University Hospital Zurich, University of Zurich, Switzerland
  • Murray, Lilly A. ORCID Lyme and Tick-Borne Diseases Research Center at Columbia University Irving Medical Center, New York, USA
  • Danelon-Sargenti, Gabriela Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Moro, Simone Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Gong, Tao Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Piffaretti, Pietro Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Bianchini, Filippo Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Crivelli, Virginia ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Podešvová, Lucie ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Pedotti, Mattia ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Jarrossay, David ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Sgrignani, Jacopo ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Thelen, Sylvia Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Uhr, Mario Synlab Suisse, Bioggio, Switzerland
  • Bernasconi, Enos ORCID Regional Hospital Lugano, Ente Ospedaliero Cantonale, Lugano, Switzerland - Università della Svizzera italiana, Lugano, Switzerland
  • Rauch, Andri ORCID Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Switzerland
  • Manzo, Antonio ORCID Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation, University of Pavia, Italy
  • Ciurea, Adrian ORCID Department of Rheumatology, University Hospital Zurich, University of Zurich, Switzerland
  • Rocchi, Marco B. L. Department of Biomolecular Sciences, Biostatistics Unit, University of Urbino, Italy
  • Varani, Luca ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Moser, Bernhard Division of Infection & Immunity, Cardiff University School of Medicine, Cardiff, UK
  • Bottazzi, Barbara ORCID IRCCS Humanitas Research Hospital, Milan, Italy
  • Thelen, Marcus ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Fallon, Brian A. Lyme and Tick-Borne Diseases Research Center at Columbia University Irving Medical Center, New York, USA - Lyme Research Program at the New York State Psychiatric Institute, New York, USA
  • Boyman, Onur ORCID Department of Immunology, University Hospital Zurich, University of Zurich, Switzerland - Faculty of Medicine and Faculty of Science, University of Zurich, Switzerland
  • Mantovani, Alberto ORCID Department of Biomedical Sciences, Humanitas University, Milan, Italy - IRCCS Humanitas Research Hospital, Milan, Italy - The William Harvey Research Institute, Queen Mary University of London, UK
  • Garzoni, Christian Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, Lugano, Switzerland
  • Franzetti-Pellanda, Alessandra Clinical Research Unit, Clinica Luganese Moncucco, Lugano, Switzerland
  • Uguccioni, Mariagrazia ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Department of Biomedical Sciences, Humanitas University, Milan, Italy
  • Robbiani, Davide F ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
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  • 2023
Published in:
  • Nature immunology. - 2023, vol. 24, p. 604-611
English Infection with severe acute respiratory syndrome coronavirus 2 associates with diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse coronavirus disease 2019 (COVID-19) outcomes. Here we discovered that antibodies against specific chemokines were omnipresent post-COVID-19, were associated with favorable disease outcome and negatively correlated with the development of long COVID at 1 yr post-infection. Chemokine antibodies were also present in HIV-1 infection and autoimmune disorders, but they targeted different chemokines compared with COVID-19. Monoclonal antibodies derived from COVID-19 convalescents that bound to the chemokine N-loop impaired cell migration. Given the role of chemokines in orchestrating immune cell trafficking, naturally arising chemokine antibodies may modulate the inflammatory response and thus bear therapeutic potential.
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  • English
Classification
Medicine
License
CC BY
Open access status
hybrid
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Persistent URL
https://n2t.net/ark:/12658/srd1330479
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