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Ripellino_2023_Wiley_Eu J Neurology_Neuropathies related to hepatitis
Journal article

Neuropathies related to hepatitis E virus infection : a prospective, matched case–control study

  • Ripellino, Paolo ORCID Department of Neurology, Neurocenter of Southern Switzerland EOC, Lugano, Switzerland - Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Lascano, Agustina Maria Neurology Division, Department of Clinical Neuroscience, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Switzerland
  • Scheidegger, Olivier ORCID Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Switzerland
  • Schilg-Hafer, Lenka Department of Neurology, Cantonal Hospital, St. Gallen, Switzerland
  • Schreiner, Bettina Department of Neurology, University and Hospital Zurich, Switzerland
  • Tsouni, Pinelopi Service de Neurologie, Hôpital du Valais, Sion, Switzerland
  • Vicino, Alex ORCID Nerve-Muscle Unit, Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland
  • Peyer, Anne-Kathrin Cantonal Hospital, Lucerne, Switzerland - Neuroliestal, Liestal, Switzerland
  • Humm, Andrea Monika Department of Medicine, Neurology Unit, HFR Fribourg Cantonal Hospital, Fribourg, Switzerland
  • Décard, Bernhard Friedrich Department of Neurology, University Hospital and University of Basel, Switzerland
  • Pianezzi, Enea Laboratory of Microbiology EOC, Bellinzona, Switzerland
  • Zezza, Giulia Laboratory of Microbiology EOC, Bellinzona, Switzerland
  • Sparasci, Davide ORCID Department of Neurology, Neurocenter of Southern Switzerland EOC, Lugano, Switzerland
  • Hundsberger, Thomas Department of Neurology, Cantonal Hospital, St. Gallen, Switzerland
  • Dietmann, Anelia ORCID Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Switzerland
  • Jung, Hans Department of Neurology, University and Hospital Zurich, Switzerland
  • Kuntzer, Thierry Nerve-Muscle Unit, Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland
  • Wilder-Smith, Einar Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Switzerland - Cantonal Hospital, Lucerne, Switzerland
  • Martinetti-Lucchini, Gladys Laboratory of Microbiology EOC, Bellinzona, Switzerland
  • Petrini, Orlando ORCID University of Applied Sciences and Arts of Southern Switzerland, Bellinzona, Switzerland
  • Fontana, Stefano Blood Transfusion Service SRC Southern Switzerland, Lugano, Switzerland - Interregional Blood Transfusion SRC, Bern, Switzerland
  • Gowland, Peter Interregional Blood Transfusion SRC, Bern, Switzerland
  • Niederhauser, Christoph Interregional Blood Transfusion SRC, Bern, Switzerland - Institute for Infectious Diseases, University of Bern, Switzerland
  • Gobbi, Claudio ORCID Department of Neurology, Neurocenter of Southern Switzerland EOC, Lugano, Switzerland - Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
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  • 2023
Published in:
  • European journal of neurology. - 2023, vol. 31, no. 1
Bell's palsy
Guillain–Barré syndrome
Hepatitis E
Neuralgic amyotrophy
Parsonage–Turner syndrome
English Background: acute hepatitis E virus (HEV) infection has recently emerged as a potential trigger for acute dysimmune neuropathies, but prospective controlled studies are lacking. Aims: to compare the frequency of concomitant acute HEV infection in patients with neuralgic amyotrophy (NA), Guillain–Barré syndrome (GBS), and Bell's palsy with a matched control population. Methods: Swiss multicenter, prospective, observational, matched case–control study over 3 years (September 2019–October 2022). Neurological cases with NA, GBS, or Bell's palsy were recruited within 1 month of disease onset. Healthy controls were matched for age, sex, geographical location, and timing of blood collection. Diagnostic criteria for acute hepatitis E were reactive serum anti-HEV IgM and IgG assays (ELISA test) and/or HEV RNA detection in serum by real-time polymerase chain reaction (RT-PCR). RT-PCR was performed on sera to confirm IgM positivity. Results: we included 180 patients (59 GBS, 51 NA, 70 Bell's palsy cases) and corresponding matched controls (blood donors) with median age 51 years for both groups and equal gender distribution. Six IgM+ cases were detected in the NA, two in the GBS, and none in the Bell's palsy group. Two controls were anti-HEV IgM-positive. At disease onset, most cases with acute HEV infection had increased liver enzymes. A moderate association (p = 0.027, Fisher's exact test; Cramér's V = −0.25) was observed only between acute HEV infection and NA. Conclusion: this prospective observational study suggests an association between concomitant acute HEV infection and NA, but not with GBS or Bell's palsy.
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  • English
Classification
Medicine
License
CC BY-NC
Open access status
hybrid
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Persistent URL
https://n2t.net/ark:/12658/srd1330471
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