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Pirosa_2024_Wiley_Hematological Oncology_Superior prognostic accuracy
Journal article

Superior prognostic accuracy of FIGO staging system in primary female genital tract lymphomas : a retrospective study (IELSG35)

  • Pirosa, Maria Cristina ORCID Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland ; Institute of Oncology Research (IOR), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Steffanoni, Sara ORCID Valduce Hospital, Como, Italy
  • Vanazzi, Anna ORCID Hemato-Oncology Division, Istituto Europeo di Oncologia, Milan, Italy
  • Esposito, Fabiana Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland
  • Polino, Angela Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland
  • Schena, Alberto Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland
  • Landi, Francesco Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland
  • Cabrera, Maria Elena ORCID Medicine Service, Hematology Section, Hospital del Salvador, University of Chile, Santiago, Chile
  • Akhtar, Saad King Faisal Specialist Hospital and Research Centre, King Abdullah Center for Oncology and Liver Disease, Riyadh, Saudi Arabia
  • Gardella, Santiago Institut Catala d'Oncologia, Girona, Spain
  • Bairey, Osnat Davidoff Cancer Center, Rabin Medical Center, Petach Tikva, Israel
  • Pavlovsky, Astrid Fundaleu-Fundación Para Combatir la Leucemia, Buenos Aires, Argentina ; Centro de Hematologia Pavlovsky, Buenos Aires, Argentina
  • Stathis, Anastasios Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland ; Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Zucca, Emanuele ORCID Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland ; Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
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  • 2024
Published in:
  • Hematological Oncology. - 2024, vol. 42, no. 6, p. e3312
Chemotherapy
CNS prophylaxis
Female reproductive system
Lymphoma
English Primary lymphoma of the female genital tract (PLFGT) is a rare type of extranodal lymphoma. In this retrospective study from the International Extranodal Lymphoma Study Group, we analyzed clinical data from 60 women diagnosed with PLFGT between 1982 and 2012. The median age was 52 years. Limited stage, as defined by the Ann Arbor and FIGO staging systems, was observed in 55% and 63% of cases, respectively. The uterus was the primary site of lymphoma in 25 cases, with the ovaries as the second most common site (n = 24). The most common histological subtype was diffuse large B-cell lymphoma (DLBCL, n = 44), followed by follicular lymphoma and marginal zone lymphoma (6 patients each). Two patients received surgery alone as first-line therapy, while 58 underwent systemic therapy, 16 following major surgery. Thirteen patients received consolidation radiotherapy and six were given central nervous system (CNS) prophylaxis. Twenty patients had disease progression or recurrence. Six patients with DLBCL (14%) experienced CNS relapse, which was the only site of recurrence in five of them. All but one patient with CNS relapse had primary ovarian involvement, and three had bulky disease; none of these patients had received CNS prophylaxis. With a median follow-up of 60 months, the median overall survival of the DLBCL cohort was approximately 13 years, with a 5-year survival rate of 77%. In multivariable analysis, advanced disease according to the FIGO system was the only parameter significantly associated with shorter overall, cause-specific, and progression-free survival in patients with DLBCL.
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  • English
Classification
Medicine
License
CC BY
Open access status
hybrid
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Persistent URL
https://n2t.net/ark:/12658/srd1330454
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