A role of FDG PET/CT for response assessment in large vessel disease?

Treglia, Giorgio; Albano, Domenico; Dondi, Francesco; Bertagna, Francesco; Gheysens, Olivier

doi:10.1053/j.semnuclmed.2022.08.002

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Journal article

A role of FDG PET/CT for response assessment in large vessel disease?

Treglia, Giorgio Clinic of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland - Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Faculty of Biology and Medicine, University of Lausanne (UNIL), Lausanne, Switzerland
Albano, Domenico Division of Nuclear Medicine, University of Brescia and Spedali Civili Brescia, Brescia, Italy
Dondi, Francesco Division of Nuclear Medicine, University of Brescia and Spedali Civili Brescia, Brescia, Italy
Bertagna, Francesco Division of Nuclear Medicine, University of Brescia and Spedali Civili Brescia, Brescia, Italy
Gheysens, Olivier Department of Nuclear Medicine, Cliniques Universitaires Saint-Luc and Institute of Clinical and Experimental Research (IREC), Université Catholique de Louvain (UCLouvain), Brussels, Belgium

2023

Published in:

Seminars in nuclear medicine. - 2023, vol. 53, no. 1, p. 78-85

English Currently, a large amount of evidence-based data clearly demonstrates the usefulness of [18F]FDG PET/CT in the diagnosis of several infectious and inflammatory diseases, including those related to the large vessels. The aim of this article is to clarify whether, beyond initial diagnosis, [18F]FDG PET/CT may have a role in treatment response assessment in inflammatory or infectious diseases of the large vessels, including large vessel vasculitis, vascular graft infection, retroperitoneal fibrosis/chronic periaortitis and infective native aortic aneurysms. Rapidly accumulating data suggest that [18F]FDG PET/CT could be a valuable imaging method for therapy monitoring in some infectious and inflammatory diseases of large vessels. The available data, albeit preliminary, indicate that [18F]FDG PET/CT could even play a pivotal role in the management of these diseases, leading to better drug dosage, confirmation of the usefulness of the treatment, and early modification of the therapeutic strategy. However, to date, the role of [18F]FDG PET/CT for treatment assessment in large vessel diseases, in particular large vessel vasculitis, is not clearly defined and well-designed prospective studies are needed to confirm its possible role in treatment monitoring and treatment guidance.

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