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Extracellular amyloid formation and associated pathology in neural grafts.
Journal article

Extracellular amyloid formation and associated pathology in neural grafts.

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  • 2003-02-25
Published in:
  • Nature neuroscience. - 2003
Alzheimer Disease
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Animals
Brain Tissue Transplantation
Diffusion
Disease Models, Animal
Extracellular Space
Gliosis
Graft Survival
Hippocampus
Mice
Mice, Transgenic
Neurons
Plaque, Amyloid
Protein Transport
Reaction Time
Solubility
Up-Regulation
English Amyloid precursor protein (APP) processing and the generation of beta-amyloid peptide (Abeta) are important in the pathogenesis of Alzheimer's disease. Although this has been studied extensively at the molecular and cellular levels, much less is known about the mechanisms of amyloid accumulation in vivo. We transplanted transgenic APP23 and wild-type B6 embryonic neural cells into the neocortex and hippocampus of both B6 and APP23 mice. APP23 grafts into wild-type hosts did not develop amyloid deposits up to 20 months after grafting. In contrast, both transgenic and wild-type grafts into young transgenic hosts developed amyloid plaques as early as 3 months after grafting. Although largely diffuse in nature, some of the amyloid deposits in wild-type grafts were congophilic and were surrounded by neuritic changes and gliosis, similar to the amyloid-associated pathology previously described in APP23 mice. Our results indicate that diffusion of soluble Abeta in the extracellular space is involved in the spread of Abeta pathology, and that extracellular amyloid formation can lead to neurodegeneration.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://susi.usi.ch/global/documents/98155
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