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Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression.
Journal article

Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression.

  • Sallusto F Institute for Research in Biomedicine, Bellinzona, Switzerland. federica.sallusto@irb.unisi.ch
  • Lanzavecchia A
  • 2001-01-04
Published in:
  • Immunological reviews. - 2000
Animals
Cell Movement
Chemokines
Dendritic Cells
Humans
Receptors, Chemokine
Signal Transduction
T-Lymphocytes
English The immune response requires a timely interaction among different cell types within distinct microenvironments. Our studies have focused on the regulation of chemokine receptors in dendritic cells (DC) and T lymphocytes. Chemokine receptors expressed by immature DC promote their migration to inflamed tissues, where antigens are captured and maturation is induced. Maturing DC upregulate CCR7, which drives their migration to the T-cell areas of the draining lymph nodes where antigen is presented to naïve T cells. DC produce a variety of chemokines that influence DC recruitment into inflamed tissues and DC-T-cell interaction in the lymph nodes. Chemokine receptors are differentially acquired by developing Th1 and Th2 cells and are differentially expressed on subsets of "central memory" and "effector memory" T cells. Furthermore, following antigenic stimulation, effector T cells can rapidly switch chemokine receptor expression, acquiring new migratory capacities. These studies provide insights into the mechanisms that control T-cell priming as well as memory and effector immune responses.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://susi.usi.ch/global/documents/62545
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