Journal article
FLU, a negative feedback regulator of tetrapyrrole biosynthesis, is physically linked to the final steps of the Mg(++)-branch of this pathway.
- Kauss D Department of Biology & Zurich-Basel Plant Science Center, ETH Zurich, Universitatstr. 2, CH-8092 Zurich, Switzerland.
- Bischof S
- Steiner S
- Apel K
- Meskauskiene R
- 2012-01-04
Published in:
- FEBS letters. - 2012
Aldehyde Oxidoreductases
Arabidopsis
Arabidopsis Proteins
Biocatalysis
Chlorophyll
Chloroplasts
Feedback, Physiological
Intracellular Membranes
Magnesium
English
Regulation of tetrapyrrole biosynthesis in higher plants has been attributed to negative feedback control. Two effectors of feedback inhibition have been identified, heme and the FLU protein. Inhibition by heme implicates the Fe-branch via regulation of the initial step of tetrapyrrole synthesis. In the present work a FLU-containing chloroplast membrane complex was identified, that besides FLU comprises the four enzymes catalyzing the final steps of chlorophyll synthesis. The results support the notion that FLU links chlorophyll synthesis and the target of feedback control, glutamyl-tRNA reductase, thereby allowing also the Mg-branch to control the initial step of tetrapyrrole synthesis.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.febslet.2011.12.029
- PMID 22212719
- Persistent URL
- https://susi.usi.ch/global/documents/36547
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