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Genetic and phenotypic intraspecific variation in the microsporidian Encephalitozoon hellem.
Journal article

Genetic and phenotypic intraspecific variation in the microsporidian Encephalitozoon hellem.

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  • 1999-07-15
Published in:
  • International journal for parasitology. - 1999
Acquired Immunodeficiency Syndrome
Animals
Base Sequence
Blotting, Western
DNA, Protozoan
DNA, Ribosomal
Encephalitozoon
Encephalitozoonosis
Genetic Variation
Genotype
Humans
Molecular Sequence Data
Parrots
Polymerase Chain Reaction
Sequence Alignment
English Encephalitozoon hellem is a microsporidian species that causes disseminated infections in HIV-positive patients. Identical genotypes of E. hellem, as assessed by the sequence of the rDNA internal transcribed spacer, have been identified in isolates from humans and from a psittacine bird. However, by analysing the rDNA ITS of four E. hellem isolates from Switzerland (three) and Tanzania (one), two new genotypes were identified. Differences among the E. hellem isolates were also detected by Western blot analysis, but there was no absolute match between ITS genotype and antigen profile. Hence, strain variation exists in E. hellem and the ITS sequence seems a valuable marker in obtaining further insight into the epidemiology of this pathogen.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://susi.usi.ch/global/documents/262905
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