Journal article
Oxetanes as versatile elements in drug discovery and synthesis.
- Burkhard JA Laboratorium für Organische Chemie, ETH Zürich, HCI H335, 8093 Zürich, Switzerland.
- Wuitschik G
- Rogers-Evans M
- Müller K
- Carreira EM
- 2010-10-30
Published in:
- Angewandte Chemie (International ed. in English). - 2010
English
Sizable resources, both financial and human, are invested each year in the development of new pharmaceutical agents. However, despite improved techniques, the new compounds often encounter difficulties in satisfying and overcoming the numerous physicochemical and many pharmacological constraints and hurdles. Oxetanes have been shown to improve key properties when grafted onto molecular scaffolds. Of particular interest are oxetanes that are substituted only in the 3-position, since such units remain achiral and their introduction into a molecular scaffold does not create a new stereocenter. This Minireview gives an overview of the recent advances made in the preparation and use of 3-substituted oxetanes. It also includes a discussion of the site-dependent modifications of various physicochemical and biochemical properties that result from the incorporation of the oxetane unit in molecular architectures.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1002/anie.200907155
- PMID 21031377
- Persistent URL
- https://susi.usi.ch/global/documents/223007
Statistics
Document views: 32
File downloads: