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mTOR signaling in cellular and organismal energetics.
Journal article

mTOR signaling in cellular and organismal energetics.

  • Albert V Biozentrum, University of Basel, CH-4056 Basel, Switzerland.
  • Hall MN Biozentrum, University of Basel, CH-4056 Basel, Switzerland. Electronic address: m.hall@unibas.ch.
  • 2015-01-03
Published in:
  • Current opinion in cell biology. - 2015
Adipose Tissue
Animals
Energy Metabolism
Homeostasis
Humans
Hypothalamus
Liver
Metabolic Diseases
Mitochondria
Muscle, Skeletal
Nucleotides
Protein Biosynthesis
Signal Transduction
TOR Serine-Threonine Kinases
English Mammalian TOR (mTOR) signaling controls growth, metabolism and energy homeostasis in a cell autonomous manner. Recent findings indicate that mTOR signaling in one tissue can also affect other organs thereby affecting whole body metabolism and energy homeostasis in a non-cell autonomous manner. It is thus not surprising that mTOR signaling mediates aging and is often deregulated in metabolic disorders, such as obesity, diabetes and cancer. This review discusses the regulation of cellular and whole body energy metabolism by mTOR, with particular focus on the non-cell autonomous function of mTOR.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://susi.usi.ch/global/documents/18035
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