Journal article
Palladium(0)-catalyzed asymmetric C(sp3)-H arylation using a chiral binol-derived phosphate and an achiral ligand.
- Yang L University of Basel , Department of Chemistry , St. Johanns-Ring 19 , CH-4056 Basel , Switzerland . Email: olivier.baudoin@unibas.ch.
- Melot R University of Basel , Department of Chemistry , St. Johanns-Ring 19 , CH-4056 Basel , Switzerland . Email: olivier.baudoin@unibas.ch.
- Neuburger M University of Basel , Department of Chemistry , St. Johanns-Ring 19 , CH-4056 Basel , Switzerland . Email: olivier.baudoin@unibas.ch.
- Baudoin O University of Basel , Department of Chemistry , St. Johanns-Ring 19 , CH-4056 Basel , Switzerland . Email: olivier.baudoin@unibas.ch.
- 2017-04-29
Published in:
- Chemical science. - 2017
English
The first efficient palladium(0)-catalyzed enantioselective C(sp3)-H activation reaction using a catalytic chiral base and an achiral phosphine ligand is reported. Fine-tuning the binol-derived phosphoric acid pre-catalyst and the reaction conditions was found to be crucial to achieve high levels of enantioselectivity for a variety of indoline products containing both tri- and tetrasubstituted stereocenters.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1039/c6sc04006c
- PMID 28451275
- Persistent URL
- https://susi.usi.ch/global/documents/123750
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