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NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?
Journal article

NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?

  • Tschopp J Department of Biochemistry, University of Lausanne, Epalinges, Switzerland. jurg.tschopp@unil.ch
  • Schroder K
  • 2010-02-20
Published in:
  • Nature reviews. Immunology. - 2010
Animals
Anti-Inflammatory Agents
Antigen-Antibody Complex
Carrier Proteins
Humans
Inflammation
Interleukin-1
Mice
Mice, Knockout
NLR Family, Pyrin Domain-Containing 3 Protein
Reactive Oxygen Species
Signal Transduction
English The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein complex that activates caspase 1, leading to the processing and secretion of the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and IL-18. The NLRP3 inflammasome is activated by a wide range of danger signals that derive not only from microorganisms but also from metabolic dysregulation. It is unclear how these highly varied stress signals can be detected by a single inflammasome. In this Opinion article, we review the different signalling pathways that have been proposed to engage the NLRP3 inflammasome and suggest a model in which one of the crucial elements for NLRP3 activation is the generation of reactive oxygen species (ROS).
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://susi.usi.ch/global/documents/105887
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