The temporal paradox of Hebbian learning and homeostatic plasticity.
- Zenke F Department of Applied Physics, Stanford University, Stanford, CA 94305, USA. Electronic address: fzenke@stanford.edu.
- Gerstner W Brain Mind Institute, School of Life Sciences and School of Computer and Communication Sciences, Ecole Polytechnique Fédérale de Lausanne, EPFL, CH-1015 Lausanne, Switzerland.
- Ganguli S Department of Applied Physics, Stanford University, Stanford, CA 94305, USA.
- 2017-04-22
Published in:
- Current opinion in neurobiology. - 2017
English
Hebbian plasticity, a synaptic mechanism which detects and amplifies co-activity between neurons, is considered a key ingredient underlying learning and memory in the brain. However, Hebbian plasticity alone is unstable, leading to runaway neuronal activity, and therefore requires stabilization by additional compensatory processes. Traditionally, a diversity of homeostatic plasticity phenomena found in neural circuits is thought to play this role. However, recent modelling work suggests that the slow evolution of homeostatic plasticity, as observed in experiments, is insufficient to prevent instabilities originating from Hebbian plasticity. To remedy this situation, we suggest that homeostatic plasticity is complemented by additional rapid compensatory processes, which rapidly stabilize neuronal activity on short timescales.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1016/j.conb.2017.03.015
- PMID 28431369
- Persistent URL
- https://susi.usi.ch/global/documents/102558
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