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Cyclic di-GMP: second messenger extraordinaire.

  • Jenal U Biozentrum of the University of Basel, Klingelbergstrasse 50/70, 4054 Basel, Switzerland.
  • Reinders A Biozentrum of the University of Basel, Klingelbergstrasse 50/70, 4054 Basel, Switzerland.
  • Lori C Biozentrum of the University of Basel, Klingelbergstrasse 50/70, 4054 Basel, Switzerland.
  • 2017-02-07
Published in:
  • Nature reviews. Microbiology. - 2017
Bacteria
Biofilms
Cyclic GMP
Dinucleoside Phosphates
Gene Expression Regulation, Bacterial
Nucleotides, Cyclic
Second Messenger Systems
Signal Transduction
English Cyclic dinucleotides (CDNs) are highly versatile signalling molecules that control various important biological processes in bacteria. The best-studied example is cyclic di-GMP (c-di-GMP). Known since the late 1980s, it is now recognized as a near-ubiquitous second messenger that coordinates diverse aspects of bacterial growth and behaviour, including motility, virulence, biofilm formation and cell cycle progression. In this Review, we discuss important new insights that have been gained into the molecular principles of c-di-GMP synthesis and degradation, which are mediated by diguanylate cyclases and c-di-GMP-specific phosphodiesterases, respectively, and the cellular functions that are exerted by c-di-GMP-binding effectors and their diverse targets. Finally, we provide a short overview of the signalling versatility of other CDNs, including c-di-AMP and cGMP-AMP (cGAMP).
Language
  • English
Open access status
green
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Persistent URL
https://susi.usi.ch/global/documents/102406
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