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Gabutti_2023_MDPI_Jcm_Circadian urinary excretion
Journal article

Circadian urinary excretion of water, and not salt, is affected by the white coat effect

  • Moretti, Fabio Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Gianini, Jvan Department of Internal Medicine, Clinical Research Unit, Regional Hospital of Bellinzona and Valli, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
  • Del Giorno, Rosaria Angiology Service, University Hospital of Lausanne, Switzerland
  • Gabutti, Luca ORCID Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Department of Internal Medicine, Clinical Research Unit, Regional Hospital of Bellinzona and Valli, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
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  • 2023
Published in:
  • Journal of clinical medicine. - 2023, vol. 12, no. 17, p. 5725
White coat effect
White coat hypertension
Hypertension
Circadian pattern
Circadian rhythm
Sodium
Sodium excretion
Salt
Water excretion
English Hypertension is an important morbidity factor. The prognostic consequences of the white-coat effect have been studied extensively. The repercussion on the circadian rhythm of urinary water and salt excretion in the same subgroup remain, conversely, among the open topics. Postulating an impaired diurnal sodium and volume excretion we decided to investigate both, in subjects with or without a white-coat effect, in the general population. A sample of 1023 subjects, has been considered. We collected 24-h urine samples, divided in day and night, and we measured the blood pressure with an Ambulatory Blood Pressure Monitoring (ABPM). ABPM values were then compared with physician collected in-office values to assign subjects to the group with or without the white-coat effect. Concerning the circadian pattern of urinary sodium excretion, we found no significant differences between the groups. There was instead in the white-coat effect group a higher night/day ratio of urinary water excretion. The white-coat effect, has been considered a potential hypertension precursor, and its consequent handling could be prospectively relevant in hypertension prevention. The absence of repercussions on the urinary circadian sodium excretion pattern and on the potentially related risk factors in subjects with a white coat effect is reassuring. The clinical significance of the impact on the night/day ratio of water excretion needs to be further investigated.
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Language
  • English
Classification
Medicine
License
CC BY
Open access status
gold
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Persistent URL
https://n2t.net/ark:/12658/srd1331923
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