Is computed-tomography-based body composition a reliable predictor of chemotherapy-related toxicity in pancreatic cancer patients?
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Cefalì, Marco
ORCID
Institute of Oncology Research (IOR), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
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Scala, Isabel
Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
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Pavone, Giuliana
ORCID
Institute of Oncology Research (IOR), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
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Helbling, Daniel
Onkozentrum Zürich, Switzerland
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Hussung, Saskia
Department of Medical Oncology and Hematology, University Hospital of Zurich, Switzerland
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Fritsch, Ralph
Department of Medical Oncology and Hematology, University Hospital of Zurich, Switzerland
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Reiner, Cäcilia
Institute for Diagnostic and Interventional Radiology, University Hospital of Zurich, Switzerland
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Stocker, Soleen
Institute for Diagnostic and Interventional Radiology, University Hospital of Zurich, Switzerland
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Koeberle, Dieter
Oncology Departement, St. Claraspital, Basel, Switzerland
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Kissling, Marc
Radiology Department, St. Claraspital, Basel, Switzerland
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Chianca, Vito
Istituto di Imaging della Svizzera Italiana (IIMSI), Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
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Del Grande, Filippo
ORCID
Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Istituto di Imaging della Svizzera Italiana (IIMSI), Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
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De Dosso, Sara
ORCID
Institute of Oncology Research (IOR), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
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Rizzo, Stefania
ORCID
Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Istituto di Imaging della Svizzera Italiana (IIMSI), Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
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Published in:
- Cancers . - 2023, vol. 15, no. 17, p. 4398
English
Background: Malnutrition, loss of weight and of skeletal muscle mass are frequent in pancreatic cancer patients, a majority of which will undergo chemotherapy over the course of their disease. Available data suggest a negative prognostic role of these changes in body composition on disease outcomes; however, it is unclear whether tolerance to chemotherapeutic treatment is similarly and/or negatively affected. We aimed to explore this association by retrospectively assessing changes in body composition and chemotherapy-related toxicity in a cohort of advanced pancreatic cancer patients. Methods: Body composition was evaluated through clinical parameters and through radiological assessment of muscle mass, skeletal muscle area, skeletal muscle index and skeletal muscle density; and an assessment of fat distribution by subcutaneous adipose tissue and visceral adipose tissue. We performed descriptive statistics, pre/post chemotherapy comparisons and uni- and multivariate analyses to assess the relation between changes in body composition and toxicity. Results: Toxicity risk increased with an increase of skeletal muscle index (OR: 1.03) and body mass index (OR: 1.07), whereas it decreased with an increase in skeletal muscle density (OR: 0.96). Multivariate analyses confirmed a reduction in the risk of toxicity only with an increase in skeletal muscle density (OR: 0.96). Conclusions: This study suggests that the retrospective analysis of changes in body composition is unlikely to be useful to predict toxicity to gemcitabine—nab-paclitaxel.
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Medicine
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CC BY
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gold
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https://n2t.net/ark:/12658/srd1331917
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