NLRC5
: back to innate immunity
- Guerra, Jessica ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
- Guarda, Greta ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
- 2024
Published in:
- Trends in immunology . - 2024
English
NLRC5 is a transcriptional regulator of genes governing T cell responses. Most characterized NLRs are instead innate immune sensors forming complexes leading to pyroptosis. Raising exciting questions, Sundaram and colleagues now demonstrate that NLRC5 forms large complexes and causes PANoptosis (immunogenic cell death), in response to heme in inflammatory contexts.
- Collections
- Language
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- English
- Classification
- Medicine
- License
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CC BY-NC-ND
- Open access status
- hybrid
- Identifiers
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- DOI 10.1016/j.it.2024.07.002
- ARK ark:/12658/srd1331167
- Persistent URL
- https://n2t.net/ark:/12658/srd1331167
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