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Scotti Gerber_2024_Karger_CaseRepNephrolDial_JC Polyomavirus
Journal article

JC polyomavirus nephropathy : a rare complication late after kidney transplantation

  • Scotti Gerber, Jennifer Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland - Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • De Marchi, Sara Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland
  • Gaspert, Ariana Department of Pathology and Molecular Pathology, University Hospital Zürich, Switzerland
  • Fehr, Thomas ORCID Department of Internal Medicine, Cantonal Hospital Graubünden, Chur, Switzerland - University of Zürich, Switzerland
  • Cippà, Pietro E. ORCID Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland - Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
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  • 2024
Published in:
  • Case reports in nephrology and dialysis. - 2024, vol. 14, no. 1, p. 148-157
Kidney transplantation
Infection
JC virus
Polyoma nephropathy
BK virus
English Introduction: JC-polyomavirus-associated nephropathy (JC-PVAN) is a rare cause of allograft dysfunction with only a few cases described in the literature. Case Presentation: we present 2 cases of JC-PVAN, both of which occurred >5 years after kidney transplantation. In both cases, transplant biopsies were performed because of worsening of kidney function. We found tubulitis and interstitial inflammation; immunohistochemistry was positive for SV40, but BK virus was not detected. The presence of JC virus confirmed the diagnosis of JC-PVAN. Immunosuppressive therapy was adopted, but in both cases graft function progressively deteriorated. Conclusions: our cases show that JC-PVAN, although much rarer than BK-PVAN, should be considered a possible cause of graft dysfunction even years after transplantation. Complete diagnostic workup, including kidney biopsy, is crucial for correct diagnosis and treatment.
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Language
  • English
Classification
Medicine
License
CC BY-NC
Open access status
hybrid
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Persistent URL
https://n2t.net/ark:/12658/srd1330483
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