ETS1 phosphorylation at threonine 38 is associated with the cell of origin of diffuse large B cell lymphoma and sustains the growth of tumour cells
- Chung, Elaine Y. L. Institute of Oncology Research (IOR), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
- Sartori, Giulio Institute of Oncology Research (IOR), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
- Ponzoni, Maurilio ORCID IRCCS San Raffaele Hospital Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
- Cascione, Luciano Institute of Oncology Research (IOR), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland
- Priebe, Valdemar Institute of Oncology Research (IOR), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
- Xu-Monette, Zijun Y. Duke University Medical Center, Durham, North Carolina, USA
- Fang, Xiaosheng ORCID Duke University Medical Center, Durham, North Carolina, USA
- Zhang, Mingzhi Duke University Medical Center, Durham, North Carolina, USA
- Visco, Carlo Section of Hematology, Department of Medicine, University of Verona, Verona, Italy
- Tzankov, Alexandar ORCID Pathology, Institute of Medical Genetics and Pathology, University Hospital, Basel, Switzerland
- Rinaldi, Andrea Institute of Oncology Research (IOR), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
- Sgrignani, Jacopo ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
- Zucca, Emanuele ORCID Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
- Rossi, Davide Institute of Oncology Research (IOR), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
- Cavalli, Andrea ORCID Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
- Inghirami, Giorgio Pathology and Laboratory Medicine Department, Weill Cornell Medicine, New York, New York, USA
- Scott, David W. Centre for Lymphoid Cancer, BC Cancer, University of British Columbia, Vancouver, British Columbia, Canada - Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
- Young, Ken H. Duke University Medical Center, Durham, North Carolina, USA
- Bertoni, Francesco ORCID Institute of Oncology Research (IOR), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
- 2023
Published in:
- British journal of haematology. - 2023, vol. 203, no. 2, p. 244-254
English
The transcriptional factor ETS1 is upregulated in 25% of diffuse large B cell lymphoma (DLBCL). Here, we studied the role of ETS1 phosphorylation at threonine 38, a marker for ETS1 activation, in DLBCL cellular models and clinical specimens. p-ETS1 was detected in activated B cell-like DLBCL (ABC), not in germinal centre B-cell-like DLBCL (GCB) cell lines and, accordingly, it was more common in ABC than GCB DLBCL diagnostic biopsies. MEK inhibition decreased both baseline and IgM stimulation-induced p-ETS1 levels. Genetic inhibition of phosphorylation of ETS1 at threonine 38 affected the growth and the BCR-mediated transcriptome program in DLBCL cell lines. Our data demonstrate that ETS1 phosphorylation at threonine 38 is important for the growth of DLBCL cells and its pharmacological inhibition could benefit lymphoma patients.
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- Language
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- English
- Classification
- Medicine
- License
- CC BY-NC-ND
- Open access status
- hybrid
- Identifiers
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- DOI 10.1111/bjh.19018
- ARK ark:/12658/srd1330232
- Persistent URL
- https://n2t.net/ark:/12658/srd1330232
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