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Bronz_2022_MDPI_children
Journal article

Köbner and Pastia signs in acute hemorrhagic edema of young children : systematic literature review

  • Bronz, Gabriel Pediatric Institute of Southern Switzerland, Ospedale San Giovanni, Ente Ospedaliero Cantonale, Bellinzona, Switzerland ; Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Consolascio, Danilo Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Bianchetti, Mario G Pediatric Institute of Southern Switzerland, Ospedale San Giovanni, Ente Ospedaliero Cantonale, Bellinzona, Switzerland ; Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Rinoldi, Pietro O. Pediatric Institute of Southern Switzerland, Ospedale San Giovanni, Ente Ospedaliero Cantonale, Bellinzona, Switzerland ; Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Betti, Céline Pediatric Institute of Southern Switzerland, Ospedale San Giovanni, Ente Ospedaliero Cantonale, Bellinzona, Switzerland ; Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Lava, Sebastiano A. G. Pediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
  • Milani, Gregorio P. Pediatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy ; Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy
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  • 2022
Published in:
  • Children. - 2022, vol. 9, no. 2, p. 265
Acute hemorrhagic edema
Cockade purpura
Finkelstein–Seidlmayer syndrome
Infantile Henoch–Schönlein syndrome
Köbner sign
Leukocytoclastic vasculitis
Pastia sign
English Acute hemorrhagic edema of young children, a benign skin-limited vasculitis, predominantly affects children 2 years of age or younger. The prevalence and clinical features of the Köbner and Pastia signs have never been systematically investigated in this vasculitis. To address this issue, we analyzed the data contained in the Acute Hemorrhagic Edema Bibliographic Database, which incorporates all reports on hemorrhagic edema published after 1969. A total of 339 cases (236 males and 103 females; 11 (8–18) months of age; median and interquartile range) were documented with at least 1 photograph and therefore included in this analysis. The Köbner sign occurred in 24 cases (14 males and 10 females; 11 (7–17) months of age), the Pastia sign in 51 cases (39 males and 12 females; 11 (8–15) months of age), and both Köbner and Pastia signs in 8 cases (7 males and 1 female;11 (7–17) months of age). The lower legs, thighs, waistline, and groin were the regions that were most commonly affected with the Köbner sign, while the ankle, feet, cubital fossa, and elbow were most affected with the Pastia sign. The Köbner and Pastia signs are clinically relevant; they occur in about every fourth child affected with hemorrhagic edema and do not influence the disease progression.
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Language
  • English
Classification
Medicine
License
CC BY
Open access status
gold
Identifiers
Persistent URL
https://n2t.net/ark:/12658/srd1325689
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