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Terziroli_2022_Spri_crai
Journal article

Infections or vaccines associated with Finkelstein-Seidlmayer vasculitis : systematic review

  • Bronz, Gabriel Pediatric Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
  • Betti, Céline Pediatric Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
  • Rinoldi, Pietro O. Pediatric Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
  • Kottanattu, Lisa Pediatric Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland - Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Bianchetti, Mario G. Family Medicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Consolascio, Danilo Family Medicine, Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland
  • Bergmann, Marcel M. ORCID Centro Pediatrico del Mendrisiotto, Mendrisio, Switzerland - Pediatric Allergy Unit, Department of Woman, Child and Adolescent, University Hospitals of Geneva, Geneva, Switzerland
  • Milani, Gregorio P. ORCID Pediatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy - Department of Clinical Sciences and Community Health, Università Degli Studi Di Milano, Milan, Italy
  • Terziroli Beretta-Piccoli, Benedetta ORCID Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Epatocentro Ticino, Lugano, Switzerland
  • Lava, Sebastiano A.G. ORCID Pediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland - Heart Failure and Transplantation, Department of Paediatric Cardiology, Great Ormond Street Hospital, London, UK
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  • 2022
Published in:
  • Clinical reviews in allergy and immunology. - 2022, vol. 63, p. 490–498
Acute hemorrhagic edema of young children
Cockade purpura with edema
Finkelstein-Seidlmayer vasculitis
Infection
Precursor
Small-vessel leukocytoclastic vasculitis
Vaccination
English Finkelstein-Seidlmayer vasculitis, also referred to as acute hemorrhagic edema of young children, is a rare small-vessel leukocytoclastic vasculitis. This condition is skin-limited, mainly affects infants up to 2 years of age and spontaneously remits. It has been suggested that an infection or a vaccine precede (by ≤ 14 days) this vasculitis. To better understand the interplay between infections or vaccines and Finkelstein-Seidlmayer vasculitis, we utilized the data contained in the Acute Hemorrhagic Edema BIbliographic Database AHEBID. The database, initiated in 2019, is being regularly updated, encompasses the entire original literature on Finkelstein-Seidlmayer vasculitis published after the original description and is attainable on request. The possible existence of an infectious or a vaccine precursor was addressed in 447 cases. Most cases were preceded by an infection (N = 384; 86%), by a vaccination (N = 20; 4.4%), or both an infection and a vaccination (N = 17; 3.8%). No precursor was reported in the remaining cases (N = 26; 5.8%). Two distinct infections preceded the onset of the vasculitis in 11 of the 381 cases with infection-associated Finkelstein-Seidlmayer vasculitis. The following infectious precursors were reported: upper respiratory tract infection (N = 292); acute gastroenteritis (N = 40); a benign febrile infection (N = 36); lower respiratory tract infection (N = 22); further infections (N = 8). The temporal relationship between the infectious precursor and the onset of the skin eruption was detailed in 336 cases: 54 cases developed before resolution and 282 after resolution of the infection. In conclusion, most cases of Finkelstein-Seidlmayer vasculitis are preceded by an infection. In a minority of cases, this skin vasculitis develops before resolution of the infection. In most cases, however, this vasculitis develops after resolution of the infection. More rarely, this vasculitis is preceded by a vaccination.
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  • English
Classification
Medicine
License
CC BY
Open access status
hybrid
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https://n2t.net/ark:/12658/srd1325677
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