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The antibody response to Plasmodium falciparum : cues for vaccine design and the discovery of receptor-based antibodies

  • Tan, Joshua Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, UK
  • Piccoli, Luca Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Lanzavecchia, Antonio Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - VIR Biotech, San Francisco, USA
    2018

26

Malaria
Sporozoites
Monoclonal antibodies
Vaccines
Antibody diversification
Receptor-based antibodies
English P. falciparum remains a serious public health problem and a continuous challenge for the immune system due to the complexity and diversity of the pathogen. Recent advances from several laboratories in the characterization of the antibody response to the parasite have led to the identification of critical targets for protection and revealed a new mechanism of diversification based on the insertion of host receptors into immunoglobulin genes, leading to the production of receptor- based antibodies. These advances have opened new possibilities for vaccine design and passive antibody therapies to provide sterilizing immunity and control blood-stage parasites.
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  • English
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Medicine
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https://n2t.net/ark:/12658/srd1319388
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