Antibody-guided vaccine design : identification of protective epitopes
- Lanzavecchia, Antonio Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Institute of Microbiology, ETH Zürich, Switzerland
- Frühwirth, Alexander Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
- Perez, Laurent Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
- Corti, Davide Humabs BioMed, Bellinzona, Switzerland
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22.06.2016
Published in:
- Current opinion in immunology. - 2016, vol. 41, no. August, p. 62-67
English
In the last decade, progress in the analysis of the human immune response and in the isolation of human monoclonal antibodies have provided an innovative approach to the identification of protective antigens which are the basis for the design of vaccines capable of eliciting effective B-cell immunity. In this review we illustrate, with relevant examples, the power of this approach that can rapidly lead to the identification of protective antigens in complex pathogens, such as human cytomegalovirus and Plasmodium falciparum, and of conserved sites in highly variable antigens, such as influenza hemagglutinin and HIV-1 Env. We will also discuss how the genealogical analysis of antigen-stimulated B cell clones provides the basis to delineate the best suitable prime-boost vaccination strategy for the induction of broadly neutralizing antibodies.
- Language
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- English
- Classification
- Medicine
- License
- CC BY-NC-ND
- Open access status
- hybrid
- Identifiers
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- RERO DOC 329937
- DOI 10.1016/j.coi.2016.06.001
- ARK ark:/12658/srd1319368
- Persistent URL
- https://n2t.net/ark:/12658/srd1319368
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