Prevalence of physiological uptake in the pancreas on somatostatin receptor-based PET/CT : a systematic review and a meta-analysis
- Boughdad, Sarah Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland
- Meyer, Marie Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland
- Prior, John O. Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland - Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
- Fernandes, Victor Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland
- Allenbach, Gilles Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland
- Kamani, Christel Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland
- Jreige, Mario Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland
- Albano, Domenico Department of Nuclear Medicine, University of Brescia and Spedali Civili Brescia, Brescia, Italy
- Bertagna, Francesco Department of Nuclear Medicine, University of Brescia and Spedali Civili Brescia, Brescia, Italy
- Nicod-Lalonde, Marie Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland
- Schaefer, Niklaus Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland - Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
- Treglia, Giorgio Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland - Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland - Clinic of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland - Academic Education, Research and Innovation Area, General Directorate, Ente Ospedaliero Cantonale, Bellinzona, Switzerland - Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
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07.05.2021
Published in:
- Clinical and Translational Imaging. - Springer. - 2021, vol. 9, no. 4, p. 353–360
English
Background: Physiological focal radiopharmaceutical uptake in the head and uncinate process of the pancreas may be seen on somatostatin receptor-based PET/CT and might lead to false-positive results for neuroendocrine tumours (NETs). We aimed to perform a systematic review and a meta-analysis about the prevalence of this finding. Methods: We performed a comprehensive computer literature search across several databases until July 2020. Pooled prevalence of physiological focal uptake on somatostatin receptor-based PET/CT in the pancreas was calculated on a per-examination- based analysis and 95% confidence interval values (95% CI) were reported. Results: Six studies (684 patients and 829 PET/CT scans) were included. The pooled prevalence of physiological uptake in the head and uncinate process of the pancreas on somatostatin receptor-based PET/CT imaging was 34% (95% CI 19.5–48.7%) with average SUVmax values ranging from 5 to 12.6. Heterogeneity was seen across the selected studies. Conclusions: High radiopharmaceutical uptake in the head and uncinate process of the pancreas is frequent at somatostatin receptor-based PET/CT and it should be recognized by nuclear medicine physicians to prevent unnecessary additional investigations. In addition, next generation PET/CT tomographs might increase the prevalence of this finding.
- Language
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- English
- Classification
- Medicine
- License
- CC BY
- Open access status
- hybrid
- Identifiers
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- RERO DOC 333680
- DOI 10.1007/s40336-021-00432-1
- ARK ark:/12658/srd1319360
- Persistent URL
- https://n2t.net/ark:/12658/srd1319360
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