Magnesium metabolism in chronic alcohol-use disorder

Vanoni, Flora O.; Milani, Gregorio P.; Agostoni, Carlo; Treglia, Giorgio; Faré, Pietro B.; Camozzi, Pietro; Lava, Sebastiano A. G.; Bianchetti, Mario G.; Janett, Simone

doi:10.3390/nu13061959

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Journal article

Magnesium metabolism in chronic alcohol-use disorder : meta-analysis and systematic review

Vanoni, Flora O. Institute of Family Medicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Milani, Gregorio P. Pediatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy - Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy - Pediatric Institute of Southern Switzerland, Ospedale San Giovanni, Bellinzona, Switzerland
Agostoni, Carlo Pediatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy - Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy
Treglia, Giorgio Academic Education, Research and Innovation Area, General Directorate, Ente Ospedaliero Cantonale, Bellinzona, Switzerland - Faculty of Biomedical Science, Università della Svizzera Italiana, Lugano, Switzerland
Faré, Pietro B. Department of Internal Medicine, Ente Ospedaliero Cantonale, Locarno, Switzerland
Camozzi, Pietro Department of Internal Medicine, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
Lava, Sebastiano A. G. Pediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
Bianchetti, Mario G. Institute of Family Medicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Janett, Simone Department of Internal Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland

2021

Published in:

Nutrients. - MDPI. - 2021, vol. 13, no. 6, p. 11

English Chronic alcohol-use disorder has been imputed as a possible cause of dietary magnesium depletion. The purpose of this study was to assess the prevalence of hypomagnesemia in chronic alcohol-use disorder, and to provide information on intracellular magnesium and on its renal handling. We carried out a structured literature search up to November 2020, which returned 2719 potentially relevant records. After excluding non-significant records, 25 were retained for the final analysis. The meta-analysis disclosed that both total and ionized circulating magnesium are markedly reduced in chronic alcohol-use disorder. The funnel plot and the Egger’s test did not disclose significant publication bias. The I2-test demonstrated significant statistical heterogeneity between studies. We also found that the skeletal muscle magnesium content is reduced and the kidney’s normal response to hypomagnesemia is blunted. In conclusion, magnesium depletion is common in chronic alcohol-use disorder. Furthermore, the kidney plays a crucial role in the development of magnesium depletion.

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