MiR-146a in immunity and disease
- Rusca, Nicole Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
- Monticelli, Silvia Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
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17.02.2011
Published in:
- Molecular biology international. - 2011, vol. 2011, p. 1-7
English
MicroRNAs (miRNAs) are regulatory molecules able to influence all aspects of the biology of a cell. They have been associated with diseases such as cancer, viral infections, and autoimmune diseases, and in recent years, they also emerged as important regulators of immune responses. MiR-146a in particular is rapidly gaining importance as a modulator of differentiation and function of cells of the innate as well as adaptive immunity. Given its importance in regulating key cellular functions, it is not surprising that miR-146a expression was also found dysregulated in different types of tumors. In this paper, we summarize recent progress in understanding the role of miR- 146a in innate and adaptive immune responses, as well as in disease.
- Language
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- English
- Classification
- Medicine
- License
- CC BY
- Open access status
- gold
- Identifiers
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- RERO DOC 326684
- DOI 10.4061/2011/437301
- ARK ark:/12658/srd1319048
- Persistent URL
- https://n2t.net/ark:/12658/srd1319048
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