MiR-146a in immunity and disease

Rusca, Nicole; Monticelli, Silvia

doi:10.4061/2011/437301

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Journal article

MiR-146a in immunity and disease

Rusca, Nicole Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
Monticelli, Silvia Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland

17.02.2011

Published in:

Molecular biology international. - 2011, vol. 2011, p. 1-7

English MicroRNAs (miRNAs) are regulatory molecules able to influence all aspects of the biology of a cell. They have been associated with diseases such as cancer, viral infections, and autoimmune diseases, and in recent years, they also emerged as important regulators of immune responses. MiR-146a in particular is rapidly gaining importance as a modulator of differentiation and function of cells of the innate as well as adaptive immunity. Given its importance in regulating key cellular functions, it is not surprising that miR-146a expression was also found dysregulated in different types of tumors. In this paper, we summarize recent progress in understanding the role of miR- 146a in innate and adaptive immune responses, as well as in disease.

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