Journal article

How computational chemistry and drug delivery techniques can support the development of new anticancer drugs

  • Garofalo, Mariangela Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Italy
  • Grazioso, Giovanni Department of Pharmaceutical Sciences, University of Milano, Italy
  • Cavalli, Andrea Swiss Institute of Bioinformatics, Lausanne, Switzerland - Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
  • Sgrignani, Jacopo Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
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    10.04.2020
Published in:
  • Molecules. - 2020, vol. 25, no. 7, p. 22 p
English The early and late development of new anticancer drugs, small molecules or peptides can be slowed down by some issues such as poor selectivity for the target or poor ADME properties. Computer-aided drug design (CADD) and target drug delivery (TDD) techniques, although apparently far from each other, are two research fields that can give a significant contribution to overcome these problems. Their combination may provide mechanistic understanding resulting in a synergy that makes possible the rational design of novel anticancer based therapies. Herein, we aim to discuss selected applications, some also from our research experience, in the fields of anticancer small organic drugs and peptides.
Language
  • English
Classification
Therapeutic, pharmacy, pharmacology
License
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Persistent URL
https://susi.usi.ch/usi/documents/319015
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