T follicular helper cells promote a beneficial gut ecosystem for host metabolic homeostasis by sensing microbiota-derived extracellular ATP
-
Perruzza, Lisa
Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland
-
Gargari, Giorgio
Department of Food, Environmental, and Nutritional Sciences (DeFENS), Universita` degli Studi di Milano, Milan, Italy
-
Proietti, Michele
Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
-
Fosso, Bruno
Institute of Biomembranes and Bioenergetics, National Research Council, Bari, Italy
-
D'Erchia, Anna Maria
Institute of Biomembranes and Bioenergetics, National Research Council, Bari, Italy - Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy
-
Faliti, Caterina Elisa
Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland
-
Rezzonico-Jost, Tanja
Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
-
Scribano, Daniela
Department of Medical and Oral Sciences and Biotechnologies, University ‘‘Gabriele D’Annunzio’’, Chieti, Italy - Departement of Public Health and Infectious Diseases, University ‘‘La Sapienza’’ of Rome, Rome, Italy
-
Mauri, Laura
Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Universita` degli Studi di Milano, Milan, Italy
-
Colombo, Diego
Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Universita` degli Studi di Milano, Milan, Italy
-
Pellegrini, Giovanni
Laboratory for Animal Model Pathology, Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
-
Moregola, Annalisa
Department of Pharmacological and Biomolecular Sciences (DiSFeB), Universita` degli Studi di Milano, Milan, Italy
-
Mooser, Catherine
Maurice Müller Laboratories, Universitätsklinik für Viszerale Chirurgie und Medizin (UVCM), University of Bern, Bern, Switzerland
-
Pesole, Graziano
Institute of Biomembranes and Bioenergetics, National Research Council, Bari, Italy - Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy
-
Nicoletti, Mauro
Department of Medical and Oral Sciences and Biotechnologies, University ‘‘Gabriele D’Annunzio’’, Chieti, Italy
-
Norata, Giuseppe Danilo
Department of Pharmacological and Biomolecular Sciences (DiSFeB), Universita` degli Studi di Milano, Milan, Italy - School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Australia
-
Geuking, Markus B.
Maurice Müller Laboratories, Universitätsklinik für Viszerale Chirurgie und Medizin (UVCM), University of Bern, Bern, Switzerland - Department of Microbiology, Immunology and Infectious Diseases and Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada
-
McCoy, Kathy D.
Maurice Müller Laboratories, Universitätsklinik für Viszerale Chirurgie und Medizin (UVCM), University of Bern, Bern, Switzerland
-
Guglielmetti, Simone
Department of Food, Environmental, and Nutritional Sciences (DeFENS), Universita` degli Studi di Milano, Milan, Italy
-
Grassi, Fabio
Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Universita` degli Studi di Milano, Milan, Italy - Istituto Nazionale Genetica Molecolare ‘‘Romeo ed Enrica Invernizzi,’’ Milan, Italy
Show more…
Published in:
- Cell reports. - 2017, vol. 18, no. 11, p. 2566-2575
English
The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer’s patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity is important for generating a diverse bacterial community in the gut and that sensing of microbiota-derived extracellular ATP via P2X7 promotes the generation of a proficient gut ecosystem for metabolic homeostasis. The results of this study indicate that Tfh cells play a role in host-microbiota mutualism beyond protecting the intestinal mucosa by induction of affinity-matured IgA and suggest that extracellular ATP constitutes an inter-kingdom signaling molecule important for selecting a beneficial microbial community for the host via P2X7-mediated regulation of B cell help.
-
Language
-
-
Classification
-
Medicine
-
License
-
License undefined
-
Identifiers
-
-
Persistent URL
-
https://n2t.net/ark:/12658/srd1318969
Statistics
Document views: 86
File downloads:
- perruzza_celrep_2017.pdf: 85