Induction of potent neutralizing antibody responses by a designed protein nanoparticle accine for respiratory syncytial virus

• Marcandalli, Jessica Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland -
• Fiala, Brooke Department of Biochemistry, University of Washington, Seattle, USA - Institute for Protein Design, University of Washington, Seattle, USA
• Ols, Sebastian Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden - Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
• Perotti, Michela Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Institute of Microbiology, ETH Zürich, Switzerland
• de van der Schueren, Willem Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, USA - Bluebird Bio, Seattle, USA
• Snijder, Joost Department of Biochemistry, University of Washington, Seattle, USA
• Hodge, Edgar Department of Medicinal Chemistry, University of Washington, Seattle, USA
• Benhaim, Mark Department of Medicinal Chemistry, University of Washington, Seattle, USA
• Ravichandran, Rashmi Department of Biochemistry, University of Washington, Seattle, USA - Institute for Protein Design, University of Washington, Seattle, USA
• Carter, Lauren Department of Biochemistry, University of Washington, Seattle, USA - Institute for Protein Design, University of Washington, Seattle, USA
• Sheffler, Will Department of Biochemistry, University of Washington, Seattle, USA - Institute for Protein Design, University of Washington, Seattle, USA
• Brunner, Livia Vaccine Formulation Laboratory, University of Lausanne, Switzerland
• Lawrenz, Maria Vaccine Formulation Institute, Godalming, UK
• Dubois, Patrice Vaccine Formulation Institute, Godalming, UK
• Lanzavecchia, Antonio Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
• Sallusto, Federica Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Institute of Microbiology, ETH Zürich, Switzerland
• Lee, Kelly K. Department of Medicinal Chemistry, University of Washington, Seattle, USA - Biological Physics Structure and Design Program, University of Washington, Seattle, USA
• Veesler, David Department of Biochemistry, University of Washington, Seattle, USA
• Correnti, Colin E. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, USA
• Stewart, Lance J. Department of Biochemistry, University of Washington, Seattle, USA - Institute for Protein Design, University of Washington, Seattle, USA
• Baker, David Department of Biochemistry, University of Washington, Seattle, USA - Institute for Protein Design, University of Washington, Seattle, USA - Howard Hughes Medical Institute, University of Washington, Seattle, USA
• Loré, Karin Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden - Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
• Perez, Laurent Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - European Virus Bioinformatics Center, Jena, Germany
• King, Neil P. Department of Biochemistry, University of Washington, Seattle, USA - Institute for Protein Design, University of Washington, Seattle, USA

Computational protein design

Self-assembly

Vaccines

Respiratory syncytial virus

Nanoparticles

Neutralizing antibodies