T regulatory cells are markers of disease activity in multiple sclerosis patients
- Dalla Libera, Dacia Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
- Di Mitri, Diletta Fondazione Santa Lucia, Rome, Italy
- Bergami, Alessandra Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
- Centonze, Diego Fondazione Santa Lucia, Rome, Italy, Dipartimento di Neuroscienze, Università Tor Vergata, Rome, Italy
- Gasperini, Claudio Lancisi Neurology Unit, San Camillo Hospital, Rome, Italy
- Grasso, Maria Grazia Fondazione Santa Lucia, Rome, Italy
- Galgani, Simona Lancisi Neurology Unit, San Camillo Hospital, Rome, Italy
- Martinelli, Vittorio Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
- Comi, Giancarlo Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
- Avolio, Carlo Department of Medical and Occupational Sciences, University of Foggia, Foggia, Italy
- Martino, Gianvito Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
- Borsellino, Giovanna Fondazione Santa Lucia, Rome, Italy
- Sallusto, Federica Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland
- Battistini,Luca Fondazione Santa Lucia, Rome, Italy
- Furlan, Roberto Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
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24.06.2011
Published in:
- Plos one. - 2011, vol. 6, no. 6, p. e21386
English
FoxP3+ Treg cells are believed to play a role in the occurrence of autoimmunity and in the determination of clinical recurrences. Contradictory reports are, however, available describing frequency and function of Treg cells during autoimmune diseases. We examined, by both polychromatic flow cytometry, and real-time RT-PCR, several Treg markers in peripheral blood mononuclear cells from patients with multiple sclerosis (MS), an autoimmune disease affecting the central nervous system. We found that Tregs, as defined by CD25, CD39, FoxP3, CTLA4, and GITR expression, were significantly decreased in stable MS patients as compared to healthy donors, but, surprisingly, restored to normal levels during an acute clinical attack. We conclude that Treg cells are not involved in causing clinical relapses, but rather react to inflammation in the attempt to restore homeostasis.
- Language
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- English
- Classification
- Medicine
- License
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CC BY
- Open access status
- gold
- Identifiers
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- RERO DOC 326640
- DOI 10.1371/journal.pone.0021386
- ARK ark:/12658/srd1318929
- Persistent URL
- https://n2t.net/ark:/12658/srd1318929
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