Post ER quality control

Fregno, Ilaria; Molinari, Maurizio

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Journal article

Post ER quality control : a role for UDP-glucose : glycoprotein glucosyl transferase and p97

Fregno, Ilaria Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Department of Biology, Swiss Federal Institute of Technology, CH-8093 Zurich, Switzerland
Molinari, Maurizio Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland - Ecole Polytechnique Fédérale de Lausanne, School of Life Sciences, CH-1015 Lausanne, Switzerland

22.07.2016

Published in:

Journal of rare diseases research & treatment. - 2016, vol. 1, no. 1, p. 40-42

Glycoprotein glucosyl transferase

Ehlers-Danlos syndrome : Idiopathic epilepsy

English Human proteinopathies are diseases caused by the expression of defective gene products. In some cases, these diseases involve the degradation of mutant but otherwise functional proteins by the quality control system of the secretory pathway. Our recent study identified two proteins that play a role in post-endoplasmic reticulum (ER) quality control and are potential targets for therapeutic treatment of several proteinopathies.

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