<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Catic, Armin</dc:creator>
  <dc:creator>Weinzierl, Andrea</dc:creator>
  <dc:creator>Heimer, Jakob</dc:creator>
  <dc:creator>Pompei, Barbara</dc:creator>
  <dc:creator>Harder, Yves</dc:creator>
  <dc:date>2024</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">ntroduced a focus on surface texturizations and a shift towards smooth breast devices, yet outcomes comparing the complication profiles of differently textured tissue expanders (TEs) remain conflicting. The study aim was to compare the complication profile of a new nanotextured and MRI-compatible TE to micro- and macrotextured TEs and to identify possible predictors for complications. Methods: A retrospective analysis of women undergoing expander-based breast reconstruction after mastectomy between January 2016 and March 2022 was conducted. The primary endpoint was the development of capsular contracture. Possible predictors were analyzed in a mixed-effects model using the least absolute shrinkage and selection operator (LASSO). Moreover, a comparison of complications and an evaluation of predictors were carried out. Results: A total of 147 breasts, encompassing 82 nanotextured, 43 microtextured and 22 macrotextured TEs, were analyzed. Breasts with nanotextured TEs were less likely to develop capsular contracture overall (OR, 0.12; 95%CI 0.05–0.28, p &lt; 0.001). Post-mastectomy radiotherapy (PMRT) was identified as a predictor for capsular contracture (OR, 4.67; 95%CI 1.86–11.71, p &lt; 0.001). Breasts with nanotextured TEs showed a higher rate of seroma, but lower rates of malposition and pain. Predictors for developing postoperative complications included higher mastectomy weight (p = 0.008). Conclusions: Breasts with nanotextured TEs exhibited the lowest rate of capsular contracture compared to micro- and macrotextured TEs. Together with its MRI-compatibility and improved oncologic follow-up, the nanotextured TE seems to be a favorable device for expander-based breast reconstruction.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://susi.usi.ch/global/documents/332004</dc:identifier>
  <dc:identifier>https://n2t.net/ark:/12658/srd1332004</dc:identifier>
  <dc:identifier>https://susi.usi.ch/documents/332004/files/Harder_2024_MDPI_jcm_Smooth operator.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.3390/jcm13195803</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/ark/12658/srd1332004</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>CC BY</dc:rights>
  <dc:source>Journal of Clinical Medicine. - 2024, vol. 13, no. 19, p. 5803</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">BIA-ALCL</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Biocompatibility </dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Breast reconstruction </dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Capsular contracture </dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Mastectomy</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Tissue expander</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Surface texturization</dc:subject>
  <dc:subject>info:eu-repo/classification/udc/61</dc:subject>
  <dc:title xmlns:ns8="xml" ns8:lang="en">Smooth operator : nanotextured breast tissue expanders are associated with lower rates of capsular contracture</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>