Bronz, Gabriel Faré, Pietro B. Lava, Sebastiano A. G. Bianchetti, Mario G. Simonetti, Giacomo D. Scoglio, Martin Terziroli Beretta-Piccoli, Benedetta Agostoni, Carlo Milani, Gregorio P. 2022 Coronavirus disease 2019 (COVID-19) and vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been associated with autoimmune phenomena. However, the interplay between COVID-19 or vaccination against SARS-CoV-2 and Berger glomerulonephritis or Henoch-Schönlein vasculitis, two diseases mediated by immunoglobulin A, has never been comprehensively investigated. Therefore, we carried out a systematic review of the literature on this topic. Following databases were used: Google Scholar, Excerpta Medica and the United States National Library of Medicine. Eighty-seven patients with immunoglobulin A-mediated diseases associated with SARS-CoV-2 infection or vaccination against coronavirus were sorted out (53% males, 47% females; 34 17-51 years of age, median and interquartile range): 47 cases of Berger glomerulonephritis and 40 of Henoch-Schönlein vasculitis. Approximately 50% (N = 24) of Berger glomerulonephritis and 10% (N = 4) of Henoch-Schönlein vasculitis patients presented with a pre-existing history of immunoglobulin A-mediated disease. Almost all cases of Berger glomerulonephritis were vaccine-associated (N = 44; 94%), while most cases of Henoch-Schönlein vasculitis were infection-associated (N = 23; 57%). Among vaccine-associated immunoglobulin A diseases, about 90% were associated to mRNA-based vaccines. Our analysis supports the hypothesis that COVID-19 and vaccination against SARS-CoV-2 may trigger or exacerbate an immunoglobulin A-mediated diseases. application/pdf https://susi.usi.ch/global/documents/325676 https://localhost:5000/ark:/12658/srd1325676 https://susi.usi.ch/documents/325676/files/Terziroli Beretta-Piccoli_2022_joa.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jaut.2022.102899 info:eu-repo/semantics/altIdentifier/ark/12658/srd1325676 info:eu-repo/semantics/openAccess CC BY Journal of autoimmunity. - 2022, vol. 132, p. 102899 Berger glomerulonephritis Coronavirus 2019 COVID 19 Henoch-schönlein vasculitis Immunoglobulin a nephritis Immunoglobulin a vasculitis Vaccination SARS-CoV-2 info:eu-repo/classification/udc/61 Coronavirus disease 2019, vaccination against coronavirus and immunoglobulin A-mediated diseases : systematic literature review http://purl.org/coar/resource_type/c_6501