Betti, Céline Camozzi, Pietro Gennaro, Viola Bianchetti, Mario G. Scoglio, Martin Simonetti, Giacomo D. Milani, Gregorio P. Lava, Sebastiano A. G. Ferrarini, Alessandra 2021-01-02 Leukocytoclastic small-vessel vasculitis of the skin (with or without systemic involvement) is often preceded by infections such as common cold, tonsillopharyngitis, or otitis media. Our purpose was to document pediatric (≤18 years) cases preceded by a symptomatic disease caused by an atypical bacterial pathogen. We performed a literature search following the Preferred Reporting of Systematic Reviews and Meta-Analyses guidelines. We retained 19 reports including 22 cases (13 females and 9 males, 1.0 to 17, median 6.3 years of age) associated with a Mycoplasma pneumoniae infection. We did not find any case linked to Chlamydophila pneumoniae, Chlamydophila psittaci, Coxiella burnetii, Francisella tularensis, or Legionella pneumophila. Patients with a systemic vasculitis (N = 14) and with a skin-limited (N = 8) vasculitis did not significantly differ with respect to gender and age. The time to recovery was ≤12 weeks in all patients with this information. In conclusion, a cutaneous small-vessel vasculitis with or without systemic involvement may occur in childhood after an infection caused by the atypical bacterial pathogen Mycoplasma pneumoniae. The clinical picture and the course of cases preceded by recognized triggers and by this atypical pathogen are indistinguishable. application/pdf https://susi.usi.ch/global/documents/319406 https://n2t.net/ark:/12658/srd1319406 https://susi.usi.ch/documents/319406/files/Betti_2021_MDPI_pathogens.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.3390/pathogens10010031 info:eu-repo/semantics/altIdentifier/ark/12658/srd1319406 info:eu-repo/semantics/openAccess CC BY Pathogens. - 2021, vol. 10, no. 1, p. 9 p Leukocytoclastic small-vessel vasculitis Atypical pathogens Mycoplasma pneumoniae Legionella pneumophila Chlamydophila pneumoniae Chlamydophila psittaci Coxiella burnetii Francisella tularensis info:eu-repo/classification/udc/616 Atypical bacterial pathogens and small-vessel leukocytoclastic vasculitis of the skin in children : systematic literature review http://purl.org/coar/resource_type/c_6501