Scappaticcio, Lorenzo Pitoia, Fabián Esposito, Katherine Piccardo, Arnoldo Trimboli, Pierpaolo 2020 Coronavirus disease 2019 (COVID-19) is the pandemic of the new millennium. COVID-19 can cause both pulmonary and systemic inflammation, potentially determining multi-organ dysfunction. Data on the relationship between COVID-19 and thyroid have been emerging, and rapidly increasing since March 2020. The thyroid gland and the virus infection with its associated inflammatory-immune responses are known to be engaged in complex interplay. SARS-CoV-2 uses ACE2 combined with the transmembrane protease serine 2 (TMPRSS2) as the key molecular complex to infect the host cells. Interestingly, ACE2 and TMPRSS2 expression levels are high in the thyroid gland and more than in the lungs. Our literature search provided greater evidence that the thyroid gland and the entire hypothalamic–pituitary–thyroid (HPT) axis could be relevant targets of damage by SARS-CoV-2. Specifically, COVID-19-related thyroid disorders include thyrotoxicosis, hypothyroidism, aswell as nonthyroidal illness syndrome. Moreover, we noticed that treatment plans for thyroid cancer are considerably changing in the direction of more teleconsultations and less diagnostic and therapeutical procedures. The current review includes findings that could be changed soon by new results on the topic, considering the rapidity of worldwide research on COVID-19. application/pdf https://localhost:5000/ark:/12658/srd1319385 https://susi.usi.ch/global/documents/319385 https://susi.usi.ch/documents/319385/files/Trimboli_riemd_2020.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1007/s11154-020-09615-z info:eu-repo/semantics/altIdentifier/ark/12658/srd1319385 info:eu-repo/semantics/openAccess CC BY Reviews in Endocrine and Metabolic Disorders. - Springer. - 2021, vol. 22, p. 803–815 Thyroid COVID-19 Hyperthyroidism Hypothyroidism Thyroid cancer info:eu-repo/classification/udc/61 Impact of COVID-19 on the thyroid gland : an update http://purl.org/coar/resource_type/c_6501