Juanola, Oriol Martínez-López, Sebastián Francés, Rubén Gómez-Hurtado, Isabel 2021-05-14 Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver disease in the Western world, probably due to the growing prevalence of obesity, metabolic diseases, and exposure to some environmental agents. In certain patients, simple hepatic steatosis can progress to non-alcoholic steatohepatitis (NASH), which can sometimes lead to liver cirrhosis and its complications including hepatocellular carcinoma. Understanding the mechanisms that cause the progression of NAFLD to NASH is crucial to be able to control the advancement of the disease. The main hypothesis considers that it is due to multiple factors that act together on genetically predisposed subjects to suffer from NAFLD including insulin resistance, nutritional factors, gut microbiota, and genetic and epigenetic factors. In this article, we will discuss the epidemiology of NAFLD, and we overview several topics that influence the development of the disease from simple steatosis to liver cirrhosis and its possible complications. application/pdf https://localhost:5000/ark:/12658/srd1319371 https://susi.usi.ch/global/documents/319371 https://susi.usi.ch/documents/319371/files/Juanola_ijerph_2021.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.3390/ijerph18105227 info:eu-repo/semantics/altIdentifier/ark/12658/srd1319371 info:eu-repo/semantics/openAccess CC BY International journal of environmental research and public health. - MDPI. - 2021, vol. 18, no. 10, p. 24 Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Obesity Metabolic syndrome Type 2 diabetes mellitus info:eu-repo/classification/udc/61 Non-alcoholic fatty liver disease : metabolic, genetic, epigenetic and environmental risk factors http://purl.org/coar/resource_type/c_6501