Vanoni, Flora O. Milani, Gregorio P. Agostoni, Carlo Treglia, Giorgio Faré, Pietro B. Camozzi, Pietro Lava, Sebastiano A. G. Bianchetti, Mario G. Janett, Simone 2021 Chronic alcohol-use disorder has been imputed as a possible cause of dietary magnesium depletion. The purpose of this study was to assess the prevalence of hypomagnesemia in chronic alcohol-use disorder, and to provide information on intracellular magnesium and on its renal handling. We carried out a structured literature search up to November 2020, which returned 2719 potentially relevant records. After excluding non-significant records, 25 were retained for the final analysis. The meta-analysis disclosed that both total and ionized circulating magnesium are markedly reduced in chronic alcohol-use disorder. The funnel plot and the Egger’s test did not disclose significant publication bias. The I2-test demonstrated significant statistical heterogeneity between studies. We also found that the skeletal muscle magnesium content is reduced and the kidney’s normal response to hypomagnesemia is blunted. In conclusion, magnesium depletion is common in chronic alcohol-use disorder. Furthermore, the kidney plays a crucial role in the development of magnesium depletion. application/pdf https://localhost:5000/ark:/12658/srd1319299 https://susi.usi.ch/global/documents/319299 https://susi.usi.ch/documents/319299/files/vanoni_n_2021.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.3390/nu13061959 info:eu-repo/semantics/altIdentifier/ark/12658/srd1319299 info:eu-repo/semantics/openAccess CC BY Nutrients. - MDPI. - 2021, vol. 13, no. 6, p. 11 Magnesium Hypomagnesemia Depletion Kidney Diet Alcohol-use Electrolytes info:eu-repo/classification/udc/61 Magnesium metabolism in chronic alcohol-use disorder : meta-analysis and systematic review http://purl.org/coar/resource_type/c_6501