<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Monticelli, Silvia</dc:creator>
  <dc:date>2019-02-20</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Upon recognition of an antigen, the differentiation of antigen-inexperienced naïve T lymphocytes into  subsets able to effectively coordinate host defense is controlled by a network of transcription factors and  regulatory molecules. In the cell nucleus, these factors act in the context of epigenetic modifications that  influence DNA accessibility and ultimately gene expression. This review discusses recent findings about  the role of DNA methylation (and its oxidized derivatives) in modulating differentiation and functions of T  helper lymphocytes of the adaptive immune system.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://susi.usi.ch/global/documents/319204</dc:identifier>
  <dc:identifier>https://localhost:5000/ark:/12658/srd1319204</dc:identifier>
  <dc:identifier>https://susi.usi.ch/documents/319204/files/Monticelli_tbs_2019.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tibs.2019.01.009</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/ark/12658/srd1319204</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>Trends in biochemical sciences. - 2019, vol. 44, no. 7, p. 589-598</dc:source>
  <dc:subject>info:eu-repo/classification/udc/57/59</dc:subject>
  <dc:title xmlns:ns1="xml" ns1:lang="en">DNA (hydroxy)methylation in T helper lymphocytes</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>