Legler, Daniel F. Thelen, Marcus 2018-01-23 Chemokine signaling is essential for coordinated cell migration in health and disease to specifically govern cell positioning in space and time. Typically, chemokines signal through heptahelical, G protein-coupled receptors to orchestrate cell migration. Notably, chemokine receptors are highly dynamic structures and signaling efficiency largely depends on the discrete contact with the ligand. Promiscuity of both chemokines and chemokine receptors, combined with biased signaling and allosteric modulation of receptor activation, guarantees a tightly controlled recruitment and positioning of individual cells within the local environment at a given time. Here, we discuss recent insights in understanding chemokine gradient formation by atypical chemokine receptors and how typical chemokine receptors can transmit distinct signals to translate guidance cues into coordinated cell locomotion in space and time. application/pdf https://susi.usi.ch/global/documents/319172 https://n2t.net/ark:/12658/srd1319172 https://susi.usi.ch/documents/319172/files/Legler_F1000R_2018.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.12688/f1000research.13130.1 info:eu-repo/semantics/altIdentifier/ark/12658/srd1319172 info:eu-repo/semantics/openAccess CC BY F1000Research. - 2018, vol. 7, p. 95 Chemokine Chemokine receptor Signal transduction GPCR info:eu-repo/classification/udc/57/59 New insights in chemokine signaling http://purl.org/coar/resource_type/c_6501