Liedtke, Alina G. Lava, Sebastiano A. G. Milani, Gregorio P. Agostoni, Carlo Gilardi, Viola Bianchetti, Mario G. Treglia, Giorgio Faré, Pietro B. 2019-12-27 Selective ß2-agonists have been imputed as potential cause of l-hyperlactatemia since the 1970s. To document the prevalence of hyperlactatemia associated with selective ß2-agonists and to investigate the predisposing factors, we searched for published articles until April 2019 pertaining to the interplay of administration of selective ß2-agonists and circulating l-lactic acid in the Excerpta Medica, Web of Science, and the U.S. National Library of Medicine databases. Out of the 1834 initially retrieved records, 56 articles were included: 42 papers reporting individual cases, 2 observational studies, and 12 clinical trials. Forty- seven individual patients receiving a selective ß2-agonist were found to have l-lactatemia ≥5.0 mmol/L, which decreased by ≥3.0 mmol/L or to ≤2.5 mmol/L after discontinuing (N = 24), reducing (N = 17) or without modifying the dosage of the selective ß2-agonist (N = 6). Clinical trials found that l-lactic acid significantly increased in healthy volunteers administered a ß2-agonist. l-lactatemia ≥5.0 mmol/L was observed in 103 (24%) out of 426 patients with asthma or preterm labor managed with a selective ß2-agonist and was more common in patients with asthma (30%) than in premature labor (5.9%). A significant relationship was also noted between l-lactate level and intravenous albuterol dose or its circulating level. In conclusion, relevant l-hyperlactatemia is common on high dose treatment with a selective ß2-agonist. application/pdf https://susi.usi.ch/global/documents/319144 https://n2t.net/ark:/12658/srd1319144 https://susi.usi.ch/documents/319144/files/Liedtke_JCM_2019.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.3390/jcm9010071 info:eu-repo/semantics/altIdentifier/ark/12658/srd1319144 info:eu-repo/semantics/openAccess CC BY Journal of clinical medicine. - 2020, vol. 9, no. 1, p. 71 Acidosis Kussmaul breathing Lactate Lactic acid ß2-adrenoceptor agonist info:eu-repo/classification/udc/61 Selective ß2-adrenoceptor agonists and relevant hyperlactatemia : systematic review and meta-analysis http://purl.org/coar/resource_type/c_6501