<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Trautwein-Weidner, Kerstin</dc:creator>
  <dc:creator>Gladiator, André</dc:creator>
  <dc:creator>Kirchner, Florian R.</dc:creator>
  <dc:creator>Becattini, Simone</dc:creator>
  <dc:creator>Rülicke, Thomas</dc:creator>
  <dc:creator>Sallusto, Federica</dc:creator>
  <dc:creator>LeibundGut-Landmann, Salomé</dc:creator>
  <dc:date>2015-10-02</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Candida spp. can cause severe and chronic mucocutaneous and systemic infections in  immunocompromised individuals. Protection from mucocutaneous candidiasis depends  on T helper cells, in particular those secreting IL-17. The events regulating T cell  activation and differentiation toward effector fates in response to fungal invasion in  different tissues are poorly understood. Here we generated a Candida-specific TCR  transgenic mouse reactive to a novel endogenous antigen that is conserved in multiple  distant species of Candida, including the clinically highly relevant C. albicans and C.  glabrata. Using TCR transgenic T cells in combination with an experimental model of  oropharyngeal candidiasis (OPC) we investigated antigen presentation and Th17 priming  by different subsets of dendritic cells (DCs) present in the infected oral mucosa. Candida- derived endogenous antigen accesses the draining lymph nodes and is directly presented  by migratory DCs. Tissue-resident Flt3L-dependent DCs and CCR2-dependent  monocyte-derived DCs collaborate in antigen presentation and T cell priming during  OPC. In contrast, Langerhans cells, which are also present in the oral mucosa and have  been shown to prime Th17 cells in the skin, are not required for induction of the Candida- specific T cell response upon oral challenge. This highlights the functional  compartmentalization of specific DC subsets in different tissues. These data provide  important new insights to our understanding of tissue-specific antifungal immunity.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://susi.usi.ch/global/documents/319083</dc:identifier>
  <dc:identifier>https://n2t.net/ark:/12658/srd1319083</dc:identifier>
  <dc:identifier>https://susi.usi.ch/documents/319083/files/Trautwein_PP_2015.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.ppat.1005164</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/ark/12658/srd1319083</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>CC BY</dc:rights>
  <dc:source>PLoS pathogens. - 2015, vol. 11, no. 10, p. e1005164</dc:source>
  <dc:subject>info:eu-repo/classification/udc/61</dc:subject>
  <dc:title xmlns:ns1="xml" ns1:lang="en">Antigen-specific Th17 cells are primed by distinct and complementary dendritic cell subsets in oropharyngeal candidiasis</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>