<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Haks, Mariëlle C.</dc:creator>
  <dc:creator>Bottazzi, Barbara</dc:creator>
  <dc:creator>Cecchinato, Valentina</dc:creator>
  <dc:creator>De Gregorio, Corinne</dc:creator>
  <dc:creator>Del Giudice, Giuseppe</dc:creator>
  <dc:creator>Kaufmann, Stefan H. E.</dc:creator>
  <dc:creator>Lanzavecchia, Antonio</dc:creator>
  <dc:creator>Lewis, David J. M.</dc:creator>
  <dc:creator>Maertzdorf, Jeroen</dc:creator>
  <dc:creator>Mantovani, Alberto</dc:creator>
  <dc:creator>Sallusto, Federica</dc:creator>
  <dc:creator>Sironi, Marina</dc:creator>
  <dc:creator>Uguccioni, Mariagrazia</dc:creator>
  <dc:creator>Ottenhoff, Tom H. M.</dc:creator>
  <dc:date>2017-11-15</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Vaccinology aims to understand what factors drive vaccine-induced immunity and protection.  For many vaccines, however, the mechanisms underlying immunity and protection remain  incompletely characterized at best, and except for neutralizing antibodies induced by viral  vaccines, few correlates of protection exist. Recent omics and systems biology big data  platforms have yielded valuable insights in these areas, particularly for viral vaccines, but in  the case of more complex vaccines against bacterial infectious diseases, understanding is  fragmented and limited. To fill this gap, the EC supported ADITEC project  (http://www.aditecproject.eu/; http://stm.sciencemag.org/content/4/128/128cm4.full) featured a  work package on “Molecular signatures of immunity and immunogenicity,” aimed to identify  key molecular mechanisms of innate and adaptive immunity during effector and memory  stages of immune responses following vaccination. Specifically, technologies were developed  to assess the human immune response to vaccination and infection at the level of the  transcriptomic and proteomic response, T-cell and B-cell memory formation, cellular  trafficking, and key molecular pathways of innate immunity, with emphasis on underlying  mechanisms of protective immunity. This work intersected with other efforts in the ADITEC  project. This review summarizes the main achievements of the work package.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://susi.usi.ch/global/documents/319034</dc:identifier>
  <dc:identifier>https://n2t.net/ark:/12658/srd1319034</dc:identifier>
  <dc:identifier>https://susi.usi.ch/documents/319034/files/haks_fimmu_2017.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2017.01563</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/ark/12658/srd1319034</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>CC BY</dc:rights>
  <dc:source>Frontiers in immunology. - 2017, vol. 8, p. 1563</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Vaccines</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Biomarkers</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Immunity and infections</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Immunity</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Assays</dc:subject>
  <dc:subject>info:eu-repo/classification/udc/61</dc:subject>
  <dc:title xmlns:ns6="xml" ns6:lang="en">Molecular signatures of immunity and immunogenicity in infection and vaccination</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>