Pedotti, Mattia Ferrero, Valentina Elisabetta Viviana Lettieri, Teresa Colpo, Pascal Follonier, Stephane Calzolai, Luigi Varani, Luca 2015-02-27 The estrogen receptor protein (ER) can bind a vast number of organic pollutants widely spread in the environment and collectively known as Endocrine Disrupting Chemicals, EDCs. Its broad selectivity makes it an ideal bio-recognition element for the detection of EDCs. Here we describe the strategy and rationale for the design of ER based biosensors and assays that generate a signal in the presence of EDCs. The opportunity to use either natural or rationally modified ER molecules is discussed. The latter approach was successfully applied in the EU-FP7 project RADAR, with the aim to develop a novel biosensor for the detection of organic pollutants both in the environment and in commercial water products. application/pdf https://n2t.net/ark:/12658/srd1319014 https://susi.usi.ch/global/documents/319014 https://susi.usi.ch/documents/319014/files/pedotti_ijerph_2015.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.3390/ijerph120302612 info:eu-repo/semantics/altIdentifier/ark/12658/srd1319014 info:eu-repo/semantics/openAccess CC BY International journal of environmental research and public health. - 2015, vol. 12, no. 3, p. 2612-2621 Estrogen receptor EDC Biosensor Pollutants info:eu-repo/classification/udc/61 Rationally modified estrogen receptor protein as a bio-recognition element for the detection of EDC pollutants : strategies and opportunities http://purl.org/coar/resource_type/c_6501