<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Gupta, Sandeep</dc:creator>
  <dc:creator>Gach, Johannes S.</dc:creator>
  <dc:creator>Becerra, Juan C.</dc:creator>
  <dc:creator>Phan, Tran B.</dc:creator>
  <dc:creator>Pudney, Jeffrey</dc:creator>
  <dc:creator>Moldoveanu, Zina</dc:creator>
  <dc:creator>Joseph, Sarah B.</dc:creator>
  <dc:creator>Landucci, Gary</dc:creator>
  <dc:creator>Supnet, Medalyn Jude</dc:creator>
  <dc:creator>Ping, Li-Hua</dc:creator>
  <dc:creator>Corti, Davide</dc:creator>
  <dc:creator>Moldt, Brian</dc:creator>
  <dc:creator>Hel, Zdenek</dc:creator>
  <dc:creator>Lanzavecchia, Antonio</dc:creator>
  <dc:creator>Ruprecht, Ruth M.</dc:creator>
  <dc:creator>Burton, Dennis R.</dc:creator>
  <dc:creator>Mestecky, Jiri</dc:creator>
  <dc:creator>Anderson, Deborah J.</dc:creator>
  <dc:creator>Forthal, Donald N.</dc:creator>
  <dc:date>2013-11-21</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">The mechanisms by which human immunodeficiency virus type 1 (HIV-1) crosses mucosal  surfaces to establish infection are unknown. Acidic genital secretions of HIV-1-infected women  contain HIV-1 likely coated by antibody. We found that the combination of acidic pH and Env- specific IgG, including that from cervicovaginal and seminal fluids of HIV-1-infected individuals,  augmented transcytosis across epithelial cells as much as 20-fold compared with Env-specific  IgG at neutral pH or non-specific IgG at either pH. Enhanced transcytosis was observed with  clinical HIV-1 isolates, including transmitted/founder strains, and was eliminated in Fc neonatal  receptor (FcRn)-knockdown epithelial cells. Non-neutralizing antibodies allowed similar or less  transcytosis than neutralizing antibodies. However, the ratio of total:infectious virus was higher  for neutralizing antibodies, indicating that they allowed transcytosis while blocking infectivity of  transcytosed virus. Immunocytochemistry revealed abundant FcRn expression in columnar  epithelia lining the human endocervix and penile urethra. Acidity and Env-specific IgG enhance  transcytosis of virus across epithelial cells via FcRn and could facilitate translocation of virus to  susceptible target cells following sexual exposure.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://localhost:5000/ark:/12658/srd1319003</dc:identifier>
  <dc:identifier>https://susi.usi.ch/global/documents/319003</dc:identifier>
  <dc:identifier>https://susi.usi.ch/documents/319003/files/Gupta_PP_2013.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.ppat.1003776</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/ark/12658/srd1319003</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>CC BY</dc:rights>
  <dc:source>Plos pathogens. - 2013, vol. 9, no. 11, p. e1003776</dc:source>
  <dc:subject>info:eu-repo/classification/udc/61</dc:subject>
  <dc:title xmlns:ns1="xml" ns1:lang="en">The neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cells</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>