Reggiori, Fulvio De Haan, Cornelis A.M. Molinari, Maurizio 2011-09-05 Pathogens of bacterial and viral origin hijack pathways operating in eukaryotic cells in many ways in order to gain access into the host, to establish themselves and to eventually produce their progeny. The detailed molecular characterization of the subversion mechanisms devised by pathogens to infect host cells is crucial to generate targets for therapeutic intervention. Here we review recent data indicating that coronaviruses probably co-opt membranous carriers derived from the endoplasmic reticulum, which contain proteins that regulate disposal of misfolded polypeptides, for their replication. In addition, we also present models describing potential mechanisms that coronaviruses could employ for this hijacking. application/pdf https://susi.usi.ch/global/documents/318948 https://n2t.net/ark:/12658/srd1318948 https://susi.usi.ch/documents/318948/files/Reggiori_V_2011.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.3390/v3091610 info:eu-repo/semantics/altIdentifier/ark/12658/srd1318948 info:eu-repo/semantics/openAccess CC BY Viruses. - 2011, vol. 3, no. 9, p. 1610-1623 Coronaviruses Nidoviruses Double-membrane vesicles MHV SARS-coronavirus Autophagy EDEMosomes EDEM1 OS-9 ERAD ER quality control info:eu-repo/classification/udc/61 Unconventional use of LC3 by coronaviruses through the alleged subversion of the ERAD tuning pathway http://purl.org/coar/resource_type/c_6501